EPHB2

Across TCGA pan-cancer cohorts, EPHB2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EPHB2 data layer compared with 31 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher EPHB2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated EPHB2 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

COAD, UCEC, and PDAC are the cancer types where EPHB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	1.000	0.889	.024	18	view →
UCEC	OS	Median	III,IV	1.000	0.531	.035	8	view →
PDAC	OS	Quartile	III,IV	0.407	0.936	.026	6	view →
GBM	OS	Median	All	0.375	0.631	.011	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

EPHB2–COAD (DFS)

Open the COAD breakdown →