EPHB2

Across TCGA cell cohorts, EPHB2 mutation is significantly associated with the RNA expression of many other genes, with 259 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible EPHB2-associated genes across cancer lineages are PTH2, CRX, and NR3C2. Each is linked with EPHB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHB2-to-partner and partner-to-EPHB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH2 grouped by EPHB2-low versus EPHB2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHB2→partner) and Y-score (partner→EPHB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PTH2 →	+0.083	+4.000	<.001	<.001	3	2
SKIN	CRX →	+0.003	+2.538	<.001	.005	3	2
SKIN	NR3C2 →	+0.527	+3.364	.001	.002	3	2
SKIN	CAPSL →	+0.509	+2.807	<.001	<.001	3	2
SKIN	DDAH1 →	+1.617	+3.169	<.001	.009	3	2
SKIN	DIRC1 →	+0.039	+3.082	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 259 associations by consensus.

PTH2 by EPHB2 expression — PANCREAS

Explore this box plot interactively →