EPHB1

Across TCGA pan-cancer cohorts, EPHB1 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated EPHB1 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher EPHB1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated EPHB1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCS, UCEC, and DLBC are the cancer types where EPHB1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	IV	0.132	0.718	.002	36	view →
UCEC	OS	Median	All	0.962	0.639	.001	36	view →
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
KIRP	OS	Median	All	0.111	0.702	.001	12	view →
ESCA	DFS	Median	II,III,IV	0.178	0.501	.006	12	view →
LUAD	DFS	Median	II,III,IV	1.000	0.398	.024	12	view →
READ	DFS	Median	III,IV	0.255	0.757	.008	9	view →
SARC	OS	Median	All	0.139	0.595	.006	6	view →
ACC	DFS	Median	II,III,IV	0.089	0.631	.032	6	view →
LUSC	OS	Median	All	0.919	0.766	.028	4	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
COAD	DFS	Median	IV	0.028	0.496	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

EPHB1–UCS (DFS)

Open the UCS breakdown →