EPHA7

Across TCGA patient cohorts, EPHA7 mutation is significantly associated with the RNA expression of many other genes, with 5,546 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHA7-associated genes across cancer lineages are SUPV3L1, MUS81, and SF3A3. Each is linked with EPHA7 in more than 4 cancer types. Because this analysis shows association rather than direction, both EPHA7-to-partner and partner-to-EPHA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUPV3L1 grouped by EPHA7-low versus EPHA7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA7→partner) and Y-score (partner→EPHA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SUPV3L1 →	+0.356	+2.010	<.001	<.001	3	5
COAD	MUS81 →	+0.286	+2.906	.004	.001	3	4
UCEC	SF3A3 →	+0.351	+2.364	<.001	<.001	3	4
COAD	NDUFS3 →	+0.469	+4.013	<.001	<.001	3	4
HNSC	NOL10 →	+0.354	+2.735	.004	.003	3	4
UCEC	DHDDS →	+0.356	+1.638	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,546 associations by consensus.

SUPV3L1 by EPHA7 expression — UCEC

Explore this box plot interactively →