EPHA7

Across TCGA patient cohorts, EPHA7 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHA7-associated genes across cancer lineages are PDCD4, Tuberin_pT1462, and 14-3-3_beta. Each is linked with EPHA7 in more than 3 cancer types. Because this analysis shows association rather than direction, both EPHA7-to-partner and partner-to-EPHA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by EPHA7-low versus EPHA7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA7→partner) and Y-score (partner→EPHA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PDCD4 →	-0.494	-2.450	.006	.020	3	4
LUAD	Tuberin_pT1462 →	+0.264	+3.000	.001	.035	3	3
SKCM	14-3-3_beta →	-0.070	-0.866	.040	.041	3	3
UCEC	Rab25 →	-0.265	-1.999	.006	.002	3	3
UCEC	STAT3_pY705 →	-0.339	-1.716	<.001	.002	3	3
UCEC	ASNS →	+0.351	+1.502	<.001	.025	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

PDCD4 by EPHA7 expression — COAD

Explore this box plot interactively →