EPHA7

Across TCGA cell cohorts, EPHA7 mutation is significantly associated with the RNA expression of many other genes, with 764 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPHA7-associated genes across cancer lineages are HSD17B6, OR6J1, and DAOA. Each is linked with EPHA7 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPHA7-to-partner and partner-to-EPHA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSD17B6 grouped by EPHA7-low versus EPHA7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA7→partner) and Y-score (partner→EPHA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSD17B6 →	+1.175	+3.459	<.001	.001	3	3
BLOOD_Lymphoma	OR6J1 →	+0.004	+4.643	<.001	.005	3	3
LUNG_NSCLC_LUAD	DAOA →	+0.008	+3.681	<.001	.009	3	2
LARGE_INTESTINE	ACBD5 →	+0.850	+3.628	<.001	<.001	3	2
LARGE_INTESTINE	UFSP2 →	+0.490	+2.502	.004	.005	3	2
LARGE_INTESTINE	ALDH6A1 →	+1.024	+3.234	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 764 associations by consensus.

HSD17B6 by EPHA7 expression — LARGE_INTESTINE

Explore this box plot interactively →