EPHA6

Across TCGA patient cohorts, EPHA6 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHA6-associated genes across cancer lineages are ATM, Smad4, and Stathmin. Each is linked with EPHA6 in more than 3 cancer types. Because this analysis shows association rather than direction, both EPHA6-to-partner and partner-to-EPHA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by EPHA6-low versus EPHA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA6→partner) and Y-score (partner→EPHA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.597	-2.234	<.001	.001	3	4
SKCM	Smad4 →	+0.065	+1.334	.025	.005	3	4
SKCM	Stathmin →	+0.122	+1.089	.008	.025	3	4
UCEC	PCNA →	+0.260	+2.146	<.001	<.001	3	4
LUSC	GATA3 →	+0.177	+3.188	.003	.009	3	3
COAD	Caspase-7-cleavedD198 →	+1.321	+2.476	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

ATM by EPHA6 expression — UCEC

Explore this box plot interactively →