EPHA6

Across TCGA cell cohorts, EPHA6 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,283 significant associations in total. KIDNEY shows the largest number of these associations.

The most reproducible EPHA6-associated GO terms across cancer lineages are Ligand-gated ion channel signaling pathway, Ionotropic glutamate receptor signaling pathway, and Neuroligin clustering involved in postsynaptic membrane assembly. Each is linked with EPHA6 in more than 5 cancer types. Because this analysis shows association rather than direction, both EPHA6-to-partner and partner-to-EPHA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ligand-gated ion channel signaling pathway grouped by EPHA6-low versus EPHA6-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA6→partner) and Y-score (partner→EPHA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Ligand-gated ion channel signaling pathway →	-0.082	-0.724	.006	.002	3	6
OVARY	Ionotropic glutamate receptor signaling pathway →	-0.085	-0.890	.003	.002	3	6
BLOOD_Myeloma	Neuroligin clustering involved in postsynaptic membrane assembly →	+1.199	+1.873	.005	.007	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of sodium ion transmembrane transporter activity →	-0.270	-0.599	<.001	.005	3	5
LUNG_NSCLC_LUAD	Synaptic transmission, glycinergic →	+0.739	+0.666	.006	<.001	3	5
STOMACH	Gamma-aminobutyric acid signaling pathway →	-0.301	-0.612	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,283 associations by consensus.

Ligand-gated ion channel signaling pathway by EPHA6 expression — OVARY

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