EPHA6

Across TCGA cell cohorts, EPHA6 mutation is significantly associated with the RNA expression of many other genes, with 455 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPHA6-associated genes across cancer lineages are PPEF2, TEX43, and KRTAP4-9. Each is linked with EPHA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHA6-to-partner and partner-to-EPHA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPEF2 grouped by EPHA6-low versus EPHA6-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA6→partner) and Y-score (partner→EPHA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PPEF2 →	+0.041	+3.906	.001	.007	3	2
LUNG_SCLC	TEX43 →	+0.130	+2.616	<.001	.005	3	2
LUNG_SCLC	KRTAP4-9 →	+0.133	+2.781	<.001	.002	3	2
CNS	APCS →	+0.163	+3.473	<.001	.001	3	2
LARGE_INTESTINE	PROP1 →	+0.013	+1.523	<.001	.006	3	2
LARGE_INTESTINE	PIGN →	+0.526	+1.807	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 455 associations by consensus.

PPEF2 by EPHA6 expression — OESOPHAGUS

Explore this box plot interactively →