EPHA5-AS1

Across TCGA pan-cancer cohorts, EPHA5-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated EPHA5-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher EPHA5-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EPHA5-AS1 expression acts as an unfavorable survival marker, although some lineages such as PRAD and PAAD show a favorable association.

KIRP, UVM, and KIRC are the cancer types where EPHA5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.362	0.733	<.001	142	view →
UVM	DFS	Tertile	III,IV	0.224	0.943	<.001	99	view →
KIRC	DFS	Tertile	II,III,IV	0.270	0.682	.001	84	view →
ACC	OS	Quartile	II,III,IV	0.647	0.902	<.001	57	view →
BLCA	OS	Quartile	IV	0.191	0.669	<.001	39	view →
BRCA	DFS	Tertile	All	0.570	1.000	.033	36	view →
LGG	OS	Tertile	All	0.407	0.601	<.001	33	view →
LIHC	OS	Tertile	All	0.622	0.808	.002	30	view →
SKCM	OS	Quartile	All	0.307	0.431	.004	19	view →
SARC	OS	Quartile	All	0.423	0.602	.013	16	view →
KICH	OS	Tertile	All	0.648	0.972	.012	9	view →
PRAD	DFS	Tertile	All	0.794	0.711	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

EPHA5-AS1–KIRP (OS)

Open the KIRP breakdown →