EPHA4

Across TCGA patient cohorts, EPHA4 protein abundance is significantly associated with the RNA expression of many other genes, with 7,921 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EPHA4-associated genes across cancer lineages are TMEM256P2, SH2D1A, and TMCC3. Each is linked with EPHA4 in more than 4 cancer types. Because this analysis shows association rather than direction, both EPHA4-to-partner and partner-to-EPHA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EPHA4 versus TMEM256P2 in LSCC, with a Pearson correlation of 0.76.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA4→partner) and Y-score (partner→EPHA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TMEM256P2 →	+1.289	+0.834	<.001	<.001	3	5
HNSC	SH2D1A →	-0.935	-0.288	<.001	.004	3	4
OV	TMCC3 →	+1.339	+0.594	.003	.003	3	3
COAD	NCS1 →	+1.088	+0.777	.005	<.001	3	3
LSCC	KCNJ2 →	+0.923	+0.579	<.001	.001	3	3
UCEC	IL21 →	-0.358	-0.521	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,921 associations by consensus.

EPHA4 vs TMEM256P2 — LSCC

Explore this scatter interactively →