EPHA4

Across TCGA patient cohorts, EPHA4 mutation is significantly associated with the RNA expression of many other genes, with 3,690 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHA4-associated genes across cancer lineages are CRYBB2P1, CXXC1, and CDC45. Each is linked with EPHA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both EPHA4-to-partner and partner-to-EPHA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBB2P1 grouped by EPHA4-low versus EPHA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA4→partner) and Y-score (partner→EPHA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CRYBB2P1 →	+0.401	+1.423	<.001	<.001	3	4
COAD	CXXC1 →	+0.469	+3.638	.004	.001	3	4
UCEC	CDC45 →	+0.508	+1.601	<.001	.001	3	4
UCEC	CDKN3 →	+0.555	+2.000	<.001	<.001	3	3
UCEC	BEX4 →	-0.682	-1.676	.003	.001	3	3
COAD	GPI →	+0.493	+3.489	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,690 associations by consensus.

CRYBB2P1 by EPHA4 expression — UCEC

Explore this box plot interactively →