EPHA4

Across TCGA cell cohorts, EPHA4 mutation is significantly associated with the RNA expression of many other genes, with 377 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPHA4-associated genes across cancer lineages are MMP26, OR52K1, and CBY1. Each is linked with EPHA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHA4-to-partner and partner-to-EPHA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by EPHA4-low versus EPHA4-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA4→partner) and Y-score (partner→EPHA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MMP26 →	+0.026	+4.807	<.001	.006	3	1
URINARY_TRACT	OR52K1 →	+0.006	+5.087	<.001	.004	3	1
LARGE_INTESTINE	CBY1 →	+0.592	+3.299	.003	.004	3	1
LARGE_INTESTINE	TNRC6B →	+0.847	+3.064	<.001	.009	3	1
LARGE_INTESTINE	TRMU →	+0.665	+3.212	.001	.006	3	1
LARGE_INTESTINE	SCML2 →	+0.975	+3.212	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 377 associations by consensus.

MMP26 by EPHA4 expression — BLOOD_Myeloma

Explore this box plot interactively →