EPHA3

Across TCGA patient cohorts, EPHA3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,915 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible EPHA3-associated genes across cancer lineages are SHH, VPS13B-DT, and SCX. Each is linked with EPHA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHA3-to-partner and partner-to-EPHA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EPHA3 versus SHH in PDAC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA3→partner) and Y-score (partner→EPHA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SHH →	+0.781	+0.390	.008	.001	3	2
LUAD	VPS13B-DT →	-0.398	-1.262	.002	.001	3	2
LSCC	SCX →	-0.999	-0.413	.001	.009	3	2
BRCA	CHD8 →	+0.647	+0.966	.002	<.001	3	1
BRCA	ZNF174 →	+0.632	+1.047	.006	.003	3	1
BRCA	BPNT2 →	+0.544	+0.714	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,915 associations by consensus.

EPHA3 vs SHH — PDAC

Explore this scatter interactively →