EPHA3

Across TCGA patient cohorts, EPHA3 mutation is significantly associated with the RNA expression of many other genes, with 4,275 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHA3-associated genes across cancer lineages are FAM177A1, SLBP, and ESS2. Each is linked with EPHA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both EPHA3-to-partner and partner-to-EPHA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM177A1 grouped by EPHA3-low versus EPHA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA3→partner) and Y-score (partner→EPHA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM177A1 →	+0.224	+1.189	.002	.001	3	4
UCEC	SLBP →	+0.325	+1.640	.002	<.001	3	4
SKCM	ESS2 →	+0.235	+1.899	.001	.001	3	4
UCEC	ACD →	+0.469	+1.555	<.001	<.001	3	4
UCEC	TPI1 →	+0.409	+1.523	<.001	<.001	3	4
UCEC	MYL12B →	+0.214	+1.315	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,275 associations by consensus.

FAM177A1 by EPHA3 expression — UCEC

Explore this box plot interactively →