EPHA3

Across TCGA cell cohorts, EPHA3 mutation is significantly associated with the RNA expression of many other genes, with 470 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPHA3-associated genes across cancer lineages are HMGB4, OR10A2, and SCAI. Each is linked with EPHA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPHA3-to-partner and partner-to-EPHA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB4 grouped by EPHA3-low versus EPHA3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA3→partner) and Y-score (partner→EPHA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HMGB4 →	+0.043	+4.906	<.001	.006	3	2
LUNG_SCLC	OR10A2 →	+0.031	+3.263	<.001	.009	3	2
SKIN	SCAI →	+0.395	+3.064	.004	.009	3	2
LARGE_INTESTINE	NOA1 →	+0.497	+3.321	.001	.003	3	2
LARGE_INTESTINE	TTK →	+0.471	+2.265	.007	.001	3	2
LARGE_INTESTINE	AMD1 →	+0.416	+3.386	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 470 associations by consensus.

HMGB4 by EPHA3 expression — OESOPHAGUS

Explore this box plot interactively →