EPHA10

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, EPHA10 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHA10-associated genes across cancer lineages are ACC_pS79, p38-MAPK_pT180_Y182, and ACC1. Each is linked with EPHA10 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPHA10-to-partner and partner-to-EPHA10 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA10→partner) and Y-score (partner→EPHA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECACC_pS79 →+0.341+2.000.002<.00133
SKCMp38-MAPK_pT180_Y182 →-0.341-2.321.002<.00133
LUSCACC1 →+0.507+3.321.005.00932
LUSCCD31 →-0.148-3.169.047.01832
STADSrc_pY527 →-0.709-3.169.003.01932
UCECeIF4E →+0.188+3.713.006<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

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