EPHA1

Across TCGA patient cohorts, EPHA1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPHA1-associated genes across cancer lineages are Caspase-7-cleavedD198, GAPDH, and INPP4B. Each is linked with EPHA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPHA1-to-partner and partner-to-EPHA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by EPHA1-low versus EPHA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPHA1→partner) and Y-score (partner→EPHA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.609	+1.700	.002	.040	3	3
SKCM	GAPDH →	+0.803	+2.321	.005	.035	3	2
UCEC	INPP4B →	-0.235	-2.415	.030	.002	3	2
UCEC	MEK1 →	+0.394	+2.201	.001	<.001	3	2
UCEC	ATM →	-0.418	-2.321	.005	.005	3	2
UCEC	4E-BP1 →	+0.238	+1.730	.008	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Caspase-7-cleavedD198 by EPHA1 expression — UCEC

Explore this box plot interactively →