EPG5

Across TCGA patient cohorts, EPG5 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPG5-associated genes across cancer lineages are ASNS, IGFBP2, and GAPDH. Each is linked with EPG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPG5-to-partner and partner-to-EPG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by EPG5-low versus EPG5-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPG5→partner) and Y-score (partner→EPG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ASNS →	+0.537	+3.000	.007	.038	3	3
BLCA	IGFBP2 →	-0.338	-1.807	.019	.026	3	3
COAD	GAPDH →	+0.351	+1.330	.045	.045	3	3
COAD	Caspase-7-cleavedD198 →	+1.204	+1.686	<.001	.013	3	3
COAD	C-Raf →	+0.129	+2.619	.010	.004	3	3
UCEC	eIF4E →	+0.157	+2.083	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

ASNS by EPG5 expression — BRCA

Explore this box plot interactively →