EPG5

Across TCGA cell cohorts, EPG5 mutation is significantly associated with the RNA expression of many other genes, with 923 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPG5-associated genes across cancer lineages are IL5RA, HES3, and EARS2. Each is linked with EPG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPG5-to-partner and partner-to-EPG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL5RA grouped by EPG5-low versus EPG5-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPG5→partner) and Y-score (partner→EPG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IL5RA →	+0.054	+2.485	.008	.002	3	3
BONE	HES3 →	+0.053	+5.169	<.001	.004	3	2
SKIN	EARS2 →	+0.529	+3.169	<.001	.009	3	2
SKIN	PSMG2 →	+0.453	+3.082	.008	.007	3	2
SKIN	HBZ →	+0.069	+3.090	<.001	.001	3	2
SKIN	ECHDC3 →	+1.097	+3.364	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 923 associations by consensus.

IL5RA by EPG5 expression — CNS

Explore this box plot interactively →