EPCAM

Across TCGA pan-cancer cohorts, EPCAM mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of EPCAM’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where EPCAM mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types EPCAM is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

CCRCC, LUAD, and HNSC are the cancer types where EPCAM tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EPCAM mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	−1.831	<.001	12	view →
LUAD	Male	All	+0.633	<.001	9	view →
HNSC	Male	III,IV	+0.806	.001	8	view →
LSCC	Male	All	+0.435	<.001	5	view →
PDAC	All	IV	+1.377	.002	3	view →
OV	All	All	+0.746	.039	2	view →
COAD	Male	III,IV	+0.409	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

EPCAM–CCRCC

Open the CCRCC breakdown →