EPC1

Across TCGA patient cohorts, EPC1 mutation is significantly associated with the RNA expression of many other genes, with 2,182 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPC1-associated genes across cancer lineages are MIR4535, RN7SL447P, and RNU6-741P. Each is linked with EPC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPC1-to-partner and partner-to-EPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4535 grouped by EPC1-low versus EPC1-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPC1→partner) and Y-score (partner→EPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	MIR4535 →	+0.509	+5.247	<.001	.006	3	3
UCEC	RN7SL447P →	+0.143	+2.097	<.001	.001	3	3
CESC	RNU6-741P →	+0.210	+5.164	<.001	.002	3	2
CESC	SNORA3C →	+0.295	+3.612	<.001	.006	3	2
BLCA	RNU1-112P →	+0.147	+4.122	<.001	.008	3	2
SKCM	MIR6752 →	+0.493	+5.199	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,182 associations by consensus.

MIR4535 by EPC1 expression — ESCA

Explore this box plot interactively →