EPC1

Across TCGA patient cohorts, EPC1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPC1-associated genes across cancer lineages are Rad50, Caspase-7-cleavedD198, and c-Met_pY1235. Each is linked with EPC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPC1-to-partner and partner-to-EPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by EPC1-low versus EPC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPC1→partner) and Y-score (partner→EPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.198	-1.502	.026	.030	3	3
UCEC	Caspase-7-cleavedD198 →	+0.749	+2.242	<.001	.005	3	3
UCEC	c-Met_pY1235 →	+0.062	+2.232	.022	.005	3	3
UCEC	mTOR_pS2448 →	-0.147	-2.439	.007	.019	3	2
UCEC	ATM →	-0.499	-2.700	.002	.006	3	2
UCEC	EGFR_pY1068 →	-0.231	-1.847	.012	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Rad50 by EPC1 expression — UCEC

Explore this box plot interactively →