EPC1

Across TCGA cell cohorts, EPC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,282 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EPC1-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Positive regulation of DNA repair, and Positive regulation of DNA metabolic process. Each is linked with EPC1 in more than 14 cancer types. Because this analysis shows association rather than direction, both EPC1-to-partner and partner-to-EPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by EPC1-low versus EPC1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EPC1→partner) and Y-score (partner→EPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of double-strand break repair →	+0.080	+0.628	<.001	<.001	3	15
SOFT_TISSUE	Positive regulation of DNA repair →	+0.066	+0.675	.002	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA metabolic process →	+0.069	+1.002	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair →	+0.086	+1.009	<.001	<.001	3	13
LUNG_SCLC	Negative regulation of gene expression, epigenetic →	+0.067	+0.542	<.001	.009	3	13
BLOOD_Myeloma	Negative regulation of transcription by RNA polymerase I →	+0.130	+0.953	.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,282 associations by consensus.

Positive regulation of double-strand break repair by EPC1 expression — OVARY

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