EPC1

Across TCGA cell cohorts, EPC1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. CNS shows the largest number of these associations.

The most reproducible EPC1-associated genes across cancer lineages are AVP, CLLU1-AS1, and SPANXN2. Each is linked with EPC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPC1-to-partner and partner-to-EPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by EPC1-low versus EPC1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPC1→partner) and Y-score (partner→EPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	2
OVARY	CLLU1-AS1 →	+0.077	+4.228	<.001	.006	3	1
OVARY	SPANXN2 →	+0.054	+4.990	<.001	.001	3	1
BLOOD_Lymphoma	DPRX →	+0.057	+4.867	<.001	.009	3	1
SKIN	SPATA31D4 →	+0.160	+4.977	<.001	.007	3	1
SKIN	SMIM36 →	+0.228	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

AVP by EPC1 expression — BLOOD_Lymphoma

Explore this box plot interactively →