EPB41L5

Across TCGA patient cohorts, EPB41L5 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPB41L5-associated genes across cancer lineages are Notch1, p62 Lck ligand, and STAT3_pY705. Each is linked with EPB41L5 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPB41L5-to-partner and partner-to-EPB41L5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by EPB41L5-low versus EPB41L5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPB41L5→partner) and Y-score (partner→EPB41L5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.143	+3.820	.002	<.001	3	3
SKCM	p62 Lck ligand →	+0.465	+3.000	.035	.036	3	2
SKCM	STAT3_pY705 →	-0.367	-3.000	.017	.036	3	2
UCEC	eIF4E →	+0.142	+3.013	.044	.018	3	2
UCEC	INPP4B →	-0.251	-1.765	.020	.013	3	2
UCEC	Ku80 →	+0.190	+1.598	.016	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Notch1 by EPB41L5 expression — UCEC

Explore this box plot interactively →