EPB41L5

Across TCGA cell cohorts, EPB41L5 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPB41L5-associated genes across cancer lineages are SLC13A1, NEUROD6, and KLHDC7B. Each is linked with EPB41L5 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPB41L5-to-partner and partner-to-EPB41L5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC13A1 grouped by EPB41L5-low versus EPB41L5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPB41L5→partner) and Y-score (partner→EPB41L5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC13A1 →	+0.015	+4.273	<.001	.006	3	1
BREAST	NEUROD6 →	+0.006	+5.781	<.001	.001	3	1
LARGE_INTESTINE	KLHDC7B →	+0.608	+3.485	<.001	.004	3	1
LARGE_INTESTINE	CBLIF →	+0.255	+3.285	.005	.007	3	1
LARGE_INTESTINE	MDGA2 →	+0.125	+2.817	<.001	.007	3	1
LARGE_INTESTINE	ECE2 →	+0.205	+2.791	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

SLC13A1 by EPB41L5 expression — SKIN

Explore this box plot interactively →