EPB41L4A

Across TCGA patient cohorts, EPB41L4A mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPB41L4A-associated genes across cancer lineages are ASNS, c-Kit, and TIGAR. Each is linked with EPB41L4A in more than 4 cancer types. Because this analysis shows association rather than direction, both EPB41L4A-to-partner and partner-to-EPB41L4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by EPB41L4A-low versus EPB41L4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPB41L4A→partner) and Y-score (partner→EPB41L4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.340	+1.459	.003	.012	3	5
COAD	c-Kit →	-0.743	-2.576	.003	.011	3	3
UCEC	TIGAR →	+0.157	+1.486	.001	.007	3	3
COAD	EGFR_pY1068 →	-0.403	-3.691	.003	.001	3	2
COAD	PDCD4 →	-0.549	-2.576	.001	.011	3	2
COAD	RAD51 →	+0.172	+3.708	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ASNS by EPB41L4A expression — UCEC

Explore this box plot interactively →