Across TCGA pan-cancer cohorts, EPB41L4A-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated EPB41L4A-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher EPB41L4A-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated EPB41L4A-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

KIRC, MESO, and ACC are the cancer types where EPB41L4A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.705	0.554	<.001	98	view →
MESO	OS	Quartile	All	0.527	0.251	.002	72	view →
ACC	DFS	Tertile	All	0.215	0.702	<.001	67	view →
UVM	DFS	Median	All	0.780	0.379	<.001	60	view →
LGG	DFS	Median	All	0.809	0.656	<.001	52	view →
OV	OS	Tertile	II,III,IV	0.260	0.363	.010	42	view →
CHOL	DFS	Tertile	II,III,IV	0.669	0.076	<.001	29	view →
LIHC	DFS	Tertile	All	0.447	0.603	.002	29	view →
ESCA	OS	Median	III,IV	0.326	0.535	.022	23	view →
KIRP	DFS	Quartile	All	0.794	0.984	.002	22	view →
BRCA	OS	Tertile	III,IV	0.955	0.855	.004	19	view →
LUAD	DFS	Tertile	II,III,IV	0.177	0.303	.030	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

Exploration

Same gene, other analysis: EPB41L4A-AS1 tumor-vs-normal RNA expression · all EPB41L4A-AS1 data types