EPB41L2

Across TCGA cell cohorts, EPB41L2 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EPB41L2-associated genes across cancer lineages are IGFL3, OR2T33, and F11. Each is linked with EPB41L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPB41L2-to-partner and partner-to-EPB41L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFL3 grouped by EPB41L2-low versus EPB41L2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPB41L2→partner) and Y-score (partner→EPB41L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IGFL3 →	+0.042	+4.705	<.001	.003	3	2
LARGE_INTESTINE	OR2T33 →	+0.112	+2.716	.005	.009	3	2
LARGE_INTESTINE	F11 →	+0.042	+2.882	<.001	.005	3	2
BLOOD_Lymphoma	ZC2HC1B →	+0.136	+4.058	<.001	.002	3	1
BLOOD_Lymphoma	RGSL1 →	+0.558	+4.295	<.001	<.001	3	1
BLOOD_Lymphoma	CBLIF →	+0.052	+3.192	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

IGFL3 by EPB41L2 expression — BLOOD_Leukemia

Explore this box plot interactively →