EPB41L1

Across TCGA pan-cancer cohorts, EPB41L1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated EPB41L1 data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher EPB41L1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated EPB41L1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and GBM are the cancer types where EPB41L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.848	0.509	.005	24	view →
PDAC	DFS	Median	All	0.497	0.331	.006	9	view →
GBM	DFS	Median	All	0.846	0.650	.008	5	view →
HNSC	DFS	Tertile	All	0.857	0.676	.020	2	view →
CCRCC	OS	Quartile	All	1.000	0.615	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

EPB41L1–LUAD (OS)

Open the LUAD breakdown →