EPB41L1

Across TCGA patient cohorts, EPB41L1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPB41L1-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and TSC1. Each is linked with EPB41L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPB41L1-to-partner and partner-to-EPB41L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by EPB41L1-low versus EPB41L1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPB41L1→partner) and Y-score (partner→EPB41L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.975	+3.008	.017	.019	3	3
UCEC	MEK1 →	+0.424	+2.058	<.001	<.001	3	3
COAD	TSC1 →	-0.289	-2.991	.043	.036	3	2
UCEC	STAT3_pY705 →	-0.322	-1.184	<.001	.022	3	2
SKCM	E-Cadherin →	-0.881	-2.222	.005	.009	3	2
UCEC	JNK2 →	+0.289	+1.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Caspase-7-cleavedD198 by EPB41L1 expression — COAD

Explore this box plot interactively →