EPB41L1

Across TCGA cell cohorts, EPB41L1 mutation is significantly associated with the RNA expression of many other genes, with 255 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EPB41L1-associated genes across cancer lineages are H1-1, PZP, and REG1A. Each is linked with EPB41L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EPB41L1-to-partner and partner-to-EPB41L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H1-1 grouped by EPB41L1-low versus EPB41L1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPB41L1→partner) and Y-score (partner→EPB41L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	H1-1 →	+0.069	+3.807	.001	.003	3	1
BREAST	PZP →	+0.384	+4.421	<.001	.004	3	1
BLOOD_Leukemia	REG1A →	+0.396	+3.803	<.001	.004	3	1
BLOOD_Leukemia	CST8 →	+0.034	+3.969	<.001	.009	3	1
BLOOD_Leukemia	OBP2B →	+0.030	+3.684	<.001	.004	3	1
BLOOD_Leukemia	LRRC55 →	+0.004	+3.922	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 255 associations by consensus.

H1-1 by EPB41L1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →