EPB41

Across TCGA pan-cancer cohorts, EPB41 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated EPB41 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher EPB41 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EPB41 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

LUAD, COAD, and CCRCC are the cancer types where EPB41 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	III,IV	0.261	0.916	.006	13	view →
COAD	DFS	Median	III,IV	1.000	0.835	.032	12	view →
CCRCC	DFS	Tertile	All	0.930	0.651	.007	11	view →
HNSC	OS	Median	II,III,IV	0.952	1.000	.016	4	view →
GBM	DFS	Median	All	0.410	0.226	.048	2	view →
PDAC	DFS	Tertile	All	0.540	0.329	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

EPB41–LUAD (DFS)

Open the LUAD breakdown →