EPB41

Across TCGA patient cohorts, EPB41 mutation is significantly associated with the RNA expression of many other genes, with 4,554 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EPB41-associated genes across cancer lineages are LSM10, RPL23AP82, and POLR2L. Each is linked with EPB41 in more than 2 cancer types. Because this analysis shows association rather than direction, both EPB41-to-partner and partner-to-EPB41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LSM10 grouped by EPB41-low versus EPB41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EPB41→partner) and Y-score (partner→EPB41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LSM10 →	+0.464	+4.044	<.001	<.001	3	3
UCEC	RPL23AP82 →	+0.530	+2.283	<.001	<.001	3	3
UCEC	POLR2L →	+0.392	+2.769	.005	<.001	3	3
UCEC	UFD1 →	+0.479	+2.326	<.001	<.001	3	3
UCEC	ENO1 →	+0.519	+2.475	<.001	<.001	3	3
UCEC	MYO15B →	-0.559	-2.169	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,554 associations by consensus.

LSM10 by EPB41 expression — UCEC

Explore this box plot interactively →