Across TCGA patient cohorts, EP400P1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EP400P1-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and ERK2. Each is linked with EP400P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EP400P1-to-partner and partner-to-EP400P1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EP400P1→partner) and Y-score (partner→EP400P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.093	-2.973	.028	.035	3	1
UCEC	A-Raf_pS299 →	-0.195	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.183	+3.169	.025	.018	3	1
UCEC	Gab2 →	+0.353	+1.700	.019	.044	3	1
UCEC	Heregulin →	-0.168	-2.000	.001	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.196	-2.209	.006	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

EP400P1 survival (RNA) · tumor vs normal (RNA) · all EP400P1 data types