Across TCGA pan-cancer cohorts, EP400 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EP400 data layer compared with 25 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EP400 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EP400 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where EP400 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.623	1.000	.003	24	view →
LSCC	OS	Tertile	II,III,IV	0.905	0.607	.021	14	view →
CCRCC	DFS	Tertile	II,III,IV	1.000	0.286	.011	10	view →
PDAC	DFS	Quartile	All	0.866	0.710	.019	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: EP400 tumor-vs-normal RNA expression · all EP400 data types