Across TCGA patient cohorts, EP400 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. COAD shows the largest number of these associations.

The most reproducible EP400-associated genes across cancer lineages are ASNS, Caveolin-1, and Caspase-7-cleavedD198. Each is linked with EP400 in more than 3 cancer types. Because this analysis shows association rather than direction, both EP400-to-partner and partner-to-EP400 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EP400→partner) and Y-score (partner→EP400) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.498	+2.000	<.001	.002	3	4
CESC	Caveolin-1 →	-0.800	-3.321	.008	.009	3	3
COAD	Caspase-7-cleavedD198 →	+1.453	+2.271	<.001	<.001	3	3
LUAD	FASN →	+0.403	+1.700	.026	.043	3	3
COAD	GAPDH →	+0.538	+1.947	<.001	<.001	3	3
COAD	ACVRL1 →	-0.210	-3.683	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Exploration

EP400 survival (RNA) · tumor vs normal (RNA) · all EP400 data types