Across TCGA cell cohorts, EP400 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,604 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EP400-associated GO terms across cancer lineages are Signal transduction in response to DNA damage, Epigenetic regulation of gene expression, and Negative regulation of gene expression, epigenetic. Each is linked with EP400 in more than 17 cancer types. Because this analysis shows association rather than direction, both EP400-to-partner and partner-to-EP400 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EP400→partner) and Y-score (partner→EP400) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Signal transduction in response to DNA damage →	+0.077	+0.733	<.001	<.001	3	18
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.069	+0.619	<.001	.002	3	17
LUNG_SCLC	Negative regulation of gene expression, epigenetic →	+0.089	+0.956	<.001	.001	3	17
SOFT_TISSUE	Heterochromatin formation →	+0.077	+0.976	<.001	<.001	3	16
LARGE_INTESTINE	Microtubule nucleation →	+0.144	+0.760	<.001	<.001	3	16
BLOOD_Myeloma	Negative regulation of sister chromatid cohesion →	+0.122	+0.529	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,604 associations by consensus.

Exploration

EP400 survival (RNA) · tumor vs normal (RNA) · all EP400 data types