Across TCGA cell cohorts, EP400 mutation is significantly associated with the RNA expression of many other genes, with 1,358 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EP400-associated genes across cancer lineages are ATF4, MTHFD2, and NDC1. Each is linked with EP400 in more than 2 cancer types. Because this analysis shows association rather than direction, both EP400-to-partner and partner-to-EP400 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EP400→partner) and Y-score (partner→EP400) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ATF4 →	+0.457	+3.290	<.001	.003	3	3
BLOOD_Leukemia	MTHFD2 →	+0.762	+3.380	<.001	.001	3	3
LARGE_INTESTINE	NDC1 →	+0.529	+2.389	<.001	<.001	3	3
LARGE_INTESTINE	JOSD1 →	+0.500	+1.483	<.001	.002	3	3
LARGE_INTESTINE	LTA4H →	+0.504	+1.780	<.001	<.001	3	3
LARGE_INTESTINE	NEDD1 →	+0.533	+1.483	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,358 associations by consensus.

Exploration

EP400 survival (RNA) · tumor vs normal (RNA) · all EP400 data types