EOMES

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, EOMES protein abundance is significantly associated with the RNA expression of many other genes, with 2,019 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EOMES-associated genes across cancer lineages are PLEKHA8, B4GALT4, and FIGNL1. Each is linked with EOMES in more than 2 cancer types. Because this analysis shows association rather than direction, both EOMES-to-partner and partner-to-EOMES results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EOMES versus PLEKHA8 in HNSC, with a Pearson correlation of -0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EOMES→partner) and Y-score (partner→EOMES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCPLEKHA8 →-1.251-0.668.008<.00132
HNSCB4GALT4 →-1.156-0.461<.001.00432
HNSCFIGNL1 →-1.303-0.572.006<.00132
HNSCZNRF3 →-1.385-0.512.006.00632
HNSCADAM20P1 →-1.041-0.701<.001<.00132
LUADNKG7 →+0.994+0.491.009.00632
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,019 associations by consensus.

EOMES vs PLEKHA8 — HNSC

Per-sample scatter of EOMES vs PLEKHA8 in HNSC (Pearson r = -0.41).

Explore this scatter interactively →

Exploration