EOMES

Across TCGA patient cohorts, EOMES mutation is significantly associated with the RNA expression of many other genes, with 3,114 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EOMES-associated genes across cancer lineages are PSMB6, NLN, and MPHOSPH10. Each is linked with EOMES in more than 3 cancer types. Because this analysis shows association rather than direction, both EOMES-to-partner and partner-to-EOMES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMB6 grouped by EOMES-low versus EOMES-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EOMES→partner) and Y-score (partner→EOMES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMB6 →	+0.497	+2.748	<.001	.003	3	4
UCEC	NLN →	+0.838	+3.247	<.001	<.001	3	3
UCEC	MPHOSPH10 →	+0.424	+2.180	.008	.009	3	3
UCEC	NARS1 →	+0.501	+2.823	.001	.001	3	3
COAD	MED9 →	+0.415	+3.223	<.001	.009	3	3
UCEC	CNIH3 →	-0.466	-3.983	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,114 associations by consensus.

PSMB6 by EOMES expression — UCEC

Explore this box plot interactively →