EOMES

Across TCGA patient cohorts, EOMES mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EOMES-associated genes across cancer lineages are FASN, PCNA, and ATM. Each is linked with EOMES in more than 2 cancer types. Because this analysis shows association rather than direction, both EOMES-to-partner and partner-to-EOMES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by EOMES-low versus EOMES-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EOMES→partner) and Y-score (partner→EOMES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.436	+3.459	.009	.005	3	3
COAD	PCNA →	+0.362	+3.178	.003	.010	3	2
COAD	ATM →	-0.917	-3.169	<.001	.017	3	2
COAD	Caspase-7-cleavedD198 →	+1.016	+2.824	.009	.034	3	2
UCEC	14-3-3_beta →	-0.119	-2.295	.005	.033	3	2
UCEC	INPP4B →	-0.360	-3.584	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

FASN by EOMES expression — UCEC

Explore this box plot interactively →