EOMES

Across TCGA cell cohorts, EOMES mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EOMES-associated genes across cancer lineages are SPIC, TNP2, and HBM. Each is linked with EOMES in more than 1 cancer types. Because this analysis shows association rather than direction, both EOMES-to-partner and partner-to-EOMES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPIC grouped by EOMES-low versus EOMES-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EOMES→partner) and Y-score (partner→EOMES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SPIC →	+0.021	+4.643	.001	.003	3	1
CNS	TNP2 →	+0.019	+4.321	<.001	.009	3	1
CNS	HBM →	+0.078	+4.754	<.001	.005	3	1
CNS	SPATA31A5 →	+0.021	+4.321	<.001	.009	3	1
LUNG_NSCLC_LUAD	ADAM30 →	+0.011	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	ZCCHC13 →	+0.017	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

SPIC by EOMES expression — CNS

Explore this box plot interactively →