EOMES

Across TCGA cell cohorts, EOMES mutation is significantly associated with the mutation status of many other genes, with 4,343 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EOMES-associated genes across cancer lineages are PCDHB5, MAP7D1, and NR0B1. Each is linked with EOMES in more than 3 cancer types. Because this analysis shows association rather than direction, both EOMES-to-partner and partner-to-EOMES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDHB5 grouped by EOMES-low versus EOMES-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EOMES→partner) and Y-score (partner→EOMES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PCDHB5 →	+3.478	+4.347	<.001	<.001	1	4
BLOOD_Leukemia	MAP7D1 →	+3.478	+4.347	<.001	<.001	1	4
LUNG_NSCLC_LUAD	NR0B1 →	+5.339	+4.772	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	CWC22 →	+5.392	+5.392	.004	.004	1	4
BLOOD_Leukemia	MEX3A →	+3.063	+3.498	.006	.006	1	4
CNS	BRD9 →	+5.614	+5.044	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,343 associations by consensus.

PCDHB5 by EOMES expression — BLOOD_Leukemia

Explore this box plot interactively →