Across TCGA patient cohorts, EOLA2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EOLA2-associated genes across cancer lineages are ATM, A-Raf_pS299, and JNK2. Each is linked with EOLA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EOLA2-to-partner and partner-to-EOLA2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EOLA2→partner) and Y-score (partner→EOLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.539	-2.459	.013	.020	3	2
UCEC	A-Raf_pS299 →	-0.147	-2.999	.010	.035	3	1
UCEC	JNK2 →	+0.332	+3.196	<.001	.009	3	1
UCEC	MEK1 →	+0.386	+2.459	.029	.020	3	1
UCEC	Notch1 →	+0.169	+3.013	.012	.018	3	1
UCEC	PDCD4 →	-0.553	-2.459	.014	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

EOLA2 survival (RNA) · tumor vs normal (RNA) · all EOLA2 data types