EOGT

Across TCGA patient cohorts, EOGT mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EOGT-associated genes across cancer lineages are GAPDH, Cyclin-B1, and 14-3-3_beta. Each is linked with EOGT in more than 1 cancer types. Because this analysis shows association rather than direction, both EOGT-to-partner and partner-to-EOGT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by EOGT-low versus EOGT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EOGT→partner) and Y-score (partner→EOGT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.493	+2.584	.012	.010	3	2
UCEC	Cyclin-B1 →	+0.776	+2.736	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.107	-1.673	.003	.040	3	1
UCEC	eEF2 →	+0.327	+1.502	.012	.030	3	1
UCEC	EGFR_pY1068 →	-0.276	-1.847	.002	.008	3	1
UCEC	eIF4E →	+0.223	+3.000	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

GAPDH by EOGT expression — UCEC

Explore this box plot interactively →