ENTR1

Across TCGA pan-cancer cohorts, ENTR1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ENTR1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ENTR1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ENTR1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where ENTR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ENTR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.391	<.001	12	view →
COAD	Female	II,III,IV	+1.541	<.001	11	view →
KIRC	Female	All	+0.510	<.001	11	view →
STAD	Male	II,III,IV	+1.389	<.001	9	view →
LIHC	Male	II,III,IV	+0.693	<.001	9	view →
LUAD	All	III,IV	+0.649	<.001	9	view →
LUSC	Female	All	+1.080	<.001	8	view →
BLCA	All	All	+0.745	<.001	8	view →
KIRP	All	II,III,IV	+0.627	<.001	8	view →
READ	All	All	+1.257	<.001	7	view →
UCEC	All	All	+0.462	.006	6	view →
BRCA	All	II,III,IV	+0.288	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ENTR1–HNSC

Open the HNSC breakdown →