ENTHD1

Across TCGA patient cohorts, ENTHD1 mutation is significantly associated with the RNA expression of many other genes, with 1,840 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENTHD1-associated genes across cancer lineages are ZWINT, WDHD1, and SPAG5. Each is linked with ENTHD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ENTHD1-to-partner and partner-to-ENTHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by ENTHD1-low versus ENTHD1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENTHD1→partner) and Y-score (partner→ENTHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZWINT →	+0.967	+3.193	.001	.009	3	4
UCEC	WDHD1 →	+0.881	+3.724	<.001	<.001	3	4
UCEC	SPAG5 →	+0.677	+3.593	.004	.001	3	4
UCEC	NUP188 →	+0.638	+3.212	<.001	.009	3	4
UCEC	DLGAP5 →	+0.949	+2.917	.001	.001	3	4
LIHC	MIR4262 →	+0.425	+5.149	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,840 associations by consensus.

ZWINT by ENTHD1 expression — LUAD

Explore this box plot interactively →