ENTHD1

Across TCGA patient cohorts, ENTHD1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ENTHD1-associated genes across cancer lineages are TFRC, Stathmin, and MEK1. Each is linked with ENTHD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ENTHD1-to-partner and partner-to-ENTHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by ENTHD1-low versus ENTHD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ENTHD1→partner) and Y-score (partner→ENTHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.738	+2.906	.001	.001	3	4
LUAD	Stathmin →	+0.338	+3.000	<.001	.036	3	2
UCEC	MEK1 →	+0.585	+3.807	<.001	<.001	3	2
SKCM	MYH11 →	-0.775	-2.807	.018	.003	3	2
SKCM	TAZ →	+0.187	+2.472	.002	.010	3	2
SKCM	Chk1 →	+0.247	+1.356	<.001	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

TFRC by ENTHD1 expression — UCEC

Explore this box plot interactively →